Domenic Burger

Former Members

Domenic Burger

About

Domenic joined the LBEM in March 2021 after previously doing his Masters in the former lab of Prof. Stahlberg. During his master studies he started working on the three-dimensional structural organisation of various alpha-synuclein fibrils which carried over into his PhD-thesis. Next to this he is establishing a workflow for cryo correlative light and electron microscopy to directly investigate the fibril conformation in brain tissue.

Current Project

Structure determination of alpha-synuclein fibrils

Fibril investigation in MSA brain

Biography

April 2020	MSc in Molecular Biology, University of Basel, Switzerland
January 2019	BSc in Biology, Major in Molecular Biology, University of Basel, Switzerland

Publications
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Ultrastructural diversity of alpha-Synuclein pathology in the post-mortem brain of Parkinson patients: implications for Lewy Body formation

Lewis, A., Van Den Heuvel, L., Di Fabrizio, M., Burger, D., Huisman, E., Bol, J.G.J.M., van de Berg, W.D.J., Stahlberg, H.

(submitted), (2026)

Synthetic alpha-synuclein fibrils replicate in mice causing MSA neuropathology

Burger, D., Kashyrina, M., Van Den Heuvel, L., de la Seigliere, H., Lewis, A., De Nuccio, F., Mohammed, I., Verchère, J., Feuillie, C., et al., Lofrumento, D.D., De Giorgi, F., Stahlberg, H., Ichas, F.

Nature 648, 409-417 (2025)

Correlative light and electron microscopy for human brain and other biological models

Shafiei, N., Stähli, D., Burger, D., Di Fabrizio, M., Van Den Heuvel, L., Daraspe, J., Böing, C., Shahmoradian, S., van de Berg, W.D.J., Genoud, C., Stahlberg, H., Lewis, A.

Nature Protocols 20, 2994–3023 (2025)

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

Böing, C., Di Fabrizio, M., Burger, D., Bol, J.G.J., Huisman, E., Rozemuller, A.J.M., van de Berg, W.D.J., Stahlberg, H., Lewis, A.

Brain 147(11), 3727-3741 (2024)

DOI: DOI

Cryo-EM structure of alpha-synuclein fibrils amplified by PMCA from PD and MSA patient brains

Burger, D., Fenyi, A., Bousset, L., Stahlberg, H., Melki, R.

bioRxiv 2021.07.08.451588, (2022)

DOI: DOI