Neurodegenerative diseases are complex problems that we aim to better understand on a structural level. Fundamentally, disease progression is strongly linked with the dysfunction and misfolding of specific proteins into fibrillar arrangementments. These fibrils are characteristically found in tissue inclusions in the human brain. Our research focuses on the  direct structure investigation of these fibrils, the morphology of the resulting tissue pathology, and was recently expanded to also include investigation in the human skin. We cover a range of different diseases, classified by four different proteins: Alpha-synuclein, Tau and Amyloid beta, and TDP-43.